The overuse of Opioid is a public health crisis. Since 1999, opioid-related deaths have significantly increased. According to the CDC report, in 2015 opioid overdose death rate were 33,091. (CDC, 2016). A study reported that the United States spent $78.5 billion annually on opioid, including $28 billion spent for health care. (Florence et al., 2013)
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